Patrick W Mantyh Selected Research

substance P-saporin

5/2006	Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs.
2/2005	Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus.
10/2002	Spinal neurons that possess the substance P receptor are required for the development of central sensitization.

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Patrick W Mantyh Research Topics

Disease

58	Pain (Aches) 01/2019 - 01/2002
26	Bone Neoplasms (Bone Cancer) 01/2019 - 10/2002
25	Neoplasms (Cancer) 01/2017 - 12/2002
12	Cancer Pain 01/2017 - 12/2002
9	Chronic Pain 01/2019 - 01/2004
6	Bone Fractures (Bone Fracture) 01/2019 - 04/2010
6	Neuralgia (Stump Neuralgia) 01/2013 - 02/2002
6	Hyperalgesia 02/2007 - 02/2002
5	Osteoarthritis 01/2019 - 02/2014
5	Disease Progression 09/2015 - 05/2005
5	Sarcoma (Soft Tissue Sarcoma) 12/2014 - 10/2005
5	Hypertrophy 09/2007 - 01/2003
4	Peripheral Nervous System Diseases (PNS Diseases) 01/2017 - 09/2006
4	Neoplasm Metastasis (Metastasis) 11/2016 - 12/2014
4	Breast Neoplasms (Breast Cancer) 11/2016 - 06/2011
4	Prostatic Neoplasms (Prostate Cancer) 09/2015 - 10/2005
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017 - 12/2005
3	Inflammation (Inflammations) 02/2007 - 02/2002
2	Sickle Cell Anemia (Hemoglobin S Disease) 01/2019 - 02/2014
2	Low Back Pain (Lumbago) 01/2019 - 02/2014
2	Wounds and Injuries (Trauma) 01/2019 - 02/2014
2	Postoperative Pain 01/2017 - 01/2015
2	Hypersensitivity (Allergy) 06/2016 - 04/2015
2	Osteoporosis 02/2014 - 01/2013
2	Neuroma 11/2011 - 12/2010
2	Lung Neoplasms (Lung Cancer) 09/2007 - 01/2007
2	Spinal Cord Injuries (Spinal Cord Injury) 05/2004 - 03/2003
2	Gliosis 03/2003 - 01/2003
2	Alzheimer Disease (Alzheimer's Disease) 03/2002 - 03/2002
1	Bone Diseases (Bone Disease) 01/2019
1	Femoral Fractures (Femoral Fracture) 11/2018
1	Adenocarcinoma 11/2016
1	Carcinoma (Carcinomatosis) 01/2016
1	Weight Loss (Weight Reduction) 12/2014
1	Head and Neck Neoplasms (Head and Neck Cancer) 12/2014

Drug/Important Bio-Agent (IBA)

20	Nerve Growth Factor (NGF)IBA 01/2019 - 05/2005
18	Analgesics (Analgesic Drugs)IBA 01/2017 - 01/2002
8	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 04/2015 - 01/2002
8	Morphine (MS Contin)FDA LinkGeneric 03/2008 - 10/2002
7	Opiate AlkaloidsIBA 01/2017 - 12/2007
5	Phosphotransferases (Kinase)IBA 01/2019 - 12/2010
4	TropomyosinIBA 01/2019 - 12/2010
4	Monoclonal AntibodiesIBA 01/2019 - 11/2007
4	Opioid Analgesics (Opioids)IBA 01/2017 - 05/2005
4	Calcitonin Gene-Related PeptideIBA 07/2012 - 11/2010
4	Proteins (Proteins, Gene)FDA Link 09/2006 - 03/2003
3	CannabinoidsIBA 01/2016 - 04/2010
3	Diphosphonates (Bisphosphonates)IBA 01/2013 - 09/2004
3	neurofilament protein HIBA 07/2012 - 11/2010
3	Peptides (Polypeptides)IBA 02/2010 - 02/2003
3	Activating Transcription Factor 3IBA 09/2007 - 05/2005
3	Glial Fibrillary Acidic ProteinIBA 09/2007 - 05/2005
3	Paclitaxel (Taxol)FDA LinkGeneric 09/2007 - 09/2006
3	Naloxone (Narcan)FDA LinkGeneric 09/2006 - 10/2002
3	substance P-saporinIBA 05/2006 - 10/2002
2	Ion Channels (Ion Channel)IBA 01/2019 - 07/2011
2	aminoalcoholphosphotransferase (AAPT)IBA 01/2017 - 03/2014
2	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2016 - 01/2013
2	AcidsIBA 08/2012 - 03/2009
2	Capsaicin (Zostrix)FDA Link 03/2009 - 10/2002
2	LigandsIBA 03/2009 - 02/2002
2	Green Fluorescent ProteinsIBA 09/2008 - 09/2004
2	Tumor Viral Antigens (Large T Antigen)IBA 09/2006 - 12/2005
2	Freund's AdjuvantIBA 05/2005 - 10/2002
2	Cytotoxins (Cytolysins)IBA 02/2005 - 10/2002
2	Substance PIBA 05/2004 - 01/2002
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 03/2004 - 12/2002
2	Amyloid (Amyloid Fibrils)IBA 03/2002 - 03/2002
1	trkA ReceptorIBA 01/2019
1	Neurotransmitter Receptors (Neurotransmitter Receptor)IBA 01/2019
1	Anesthetics (Anesthetic Agents)IBA 01/2017
1	Reactive Nitrogen SpeciesIBA 11/2016
1	AntiportersIBA 11/2016
1	Glutamic Acid (Glutamate)FDA Link 11/2016
1	Cystine (L-Cystine)IBA 11/2016
1	IronIBA 11/2016
1	PorphyrinsIBA 11/2016
1	SymportersIBA 11/2016
1	Peroxynitrous Acid (Peroxynitrite)IBA 11/2016
1	Purinergic P2X3 ReceptorsIBA 06/2016
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2016
1	JHW 015IBA 01/2016
1	CalciumIBA 01/2016
1	LuciferasesIBA 01/2016
1	pexidartinibIBA 09/2015
1	Formaldehyde (Formol)FDA Link 09/2015
1	AnisomycinIBA 04/2015
1	CarrageenanIBA 04/2015
1	Dopamine (Intropin)FDA LinkGeneric 04/2015
1	Dinoprostone (PGE2)FDA Link 04/2015

Therapy/Procedure

38	Therapeutics 01/2019 - 01/2004
4	Drug Therapy (Chemotherapy) 01/2019 - 10/2002
4	Orthopedic Procedures 01/2019 - 02/2014
3	Analgesia 01/2013 - 10/2005
2	Intravenous Administration 09/2008 - 03/2008
2	Intravenous Infusions 09/2007 - 01/2007
1	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2017
1	Physical Therapy Modalities (Physical Therapy Technique) 01/2017
1	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2017
1	Replacement Arthroplasty 01/2015